Iran and the major world powers signed the agreement known as the Joint Comprehensive Plan of Action (JCPOA) in 2015. Under the agreement, Iran accepted to curb its nuclear program in exchange for economic sanctions relief.
The US President Donald Trump since his inauguration as the successor of Barack Obama has threatened that he would either kill the JCPOA or make some changes in the deal.
'No negotiation on the JCPOA is the absolute decision and strategy of the Islamic Republic [of Iran],' Ahmad Khatami said in his sermons on Friday.
'The Americans have adopted four strategies in the face of Iran and Muslim countries and the region,' he said.
They are trying to weaken Iran's defensive and missile capabilities, so that the occupying Zionist regime remains safe,' said the leader of Friday prayer.
Iran will not negotiate again on its defense and missile programs with any party, and will not allow any state to meddle in the issue, he said.
The US is also seeking to boost terrorist and Takfiri groups to make the region insecure, so that the Zionist regime remains safe, and they achieve their goals, Khatami said.